It can take up to 24 hours to completely rid your system of ibuprofen, even though its effects generally last about 4 to 6 hours. According to the prescribing information, the ibuprofen half-life is about two hours. In case of an ibuprofen overdose, call 911 or Poison Control at 800-222-1222.
What does ibuprofen do?
Ibuprofen reduces production of chemicals called prostaglandins. Prostaglandins are involved in pathways that produce pain, swelling and fever. Ibuprofen uses include relieving pain, inflammation and fever. Prostaglandins also promote blood clotting. So, ibuprofen is a mild blood thinner that can slow clotting.